Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II
نویسندگان
چکیده
منابع مشابه
Functions of Mediator and the RNA Polymerase II C-terminal Domain in TranscriptiFunctions of Mediator and the RNA Polymerase II C-terminal Domain in Transcription Initiation
متن کامل
RNA polymerase II transcription: structure and mechanism.
A minimal RNA polymerase II (pol II) transcription system comprises the polymerase and five general transcription factors (GTFs) TFIIB, -D, -E, -F, and -H. The addition of Mediator enables a response to regulatory factors. The GTFs are required for promoter recognition and the initiation of transcription. Following initiation, pol II alone is capable of RNA transcript elongation and of proofrea...
متن کاملRECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription
It is known that transcription can induce DNA recombination, thus compromising genomic stability. RECQ5 DNA helicase promotes genomic stability by regulating homologous recombination. Recent studies have shown that RECQ5 forms a stable complex with RNA polymerase II (RNAPII) in human cells, but the cellular role of this association is not understood. Here, we provide evidence that RECQ5 specifi...
متن کاملCross-Talk of Phosphorylation and Prolyl Isomerization of the C-terminal Domain of RNA Polymerase II
Post-translational modifications of the heptad repeat sequences in the C-terminal domain (CTD) of RNA polymerase II (Pol II) are well recognized for their roles in coordinating transcription with other nuclear processes that impinge upon transcription by the Pol II machinery; and this is primarily achieved through CTD interactions with the various nuclear factors. The identification of novel mo...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0174-3